The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not associated to SET-area proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a number of proteins in addition to histones (see later); they need to due to this fact be named protein lysine methyltransferases fairly than histone lysine methyltransferases.
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