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The exception to the rule is the DOT1 family, lawyers in my area members of which methylate K79 in the globular region of histone H3 and that are structurally not associated to SET-area proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a number of proteins in addition to histones (see later); they need to due to this fact be named protein lysine methyltransferases fairly than histone lysine methyltransferases.

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