Cannabinoids, the active compounds in cannabis, have been extensively studied for their potential in managing chronic pain. Recent research provides insights into their efficacy and safety: Comparative Effectiveness with Opioids A systematic review and network meta-analysis evaluated the benefits and harms of medical cannabis versus opioids for chronic non-cancer pain. The study found that both cannabinoids and opioids offer small improvements in pain relief, j weed pen physical functioning, and sleep quality compared to placebo.
Notably, cannabis resulted in fewer discontinuations due to adverse events than opioids, suggesting a more favorable safety profile. BMJ OPEN Clinical Practice Guidelines The BMJ issued a clinical practice guideline recommending a trial of non-inhaled medical cannabis or cannabinoids for individuals with chronic pain unresponsive to standard care.
